Individuals with MTHFR mutations and slow COMT activity can generally take N acetylcysteine (NAC) and glutathione, but there are some important considerations: ## N Acetylcysteine (NAC) * **Benefits**: NAC supports the production of glutathione, Not all supplements work the same. Some just add. Some activate. NAC is your body's antioxidant switchfueling glutathione, calming the brain, and supporting immunity. This is how real health works. From the N acetyl L Cysteine Glutathione Getting the k'NAC'k of Parkinson's disease The Science of Parkinson's L Glutathione VS NAC: Differences, Similarities, and Uses NAC vs Glutathione: Which Antioxidant Is Right for You? Momentous