Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway Particle FOXO4 DRI (Proxofim) is a synthetic peptide with a retro inverted structure, developed as a modified version of the natural FOXO4 protein. Scientific interest in this compound is growing, especially within The FOXO4 peptide in a DRI conformation (D amino acids in a retro reversed sequence), henceforth named FOXO4 DRI, competes with FOXO4 for p53 binding in a dose dependent manner and doing so with higher affinity. FOXO4 Wikipedia FOXO4 DRI UK Senolytic Peptide Research Peptides Lab UK FOXO4 DRI alleviates age related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice Aging